Lightly grease a baking dish or line it with parchment paper.
Prepare the Chicken:
Pat the chicken breasts dry with paper towels.
Season both sides of the chicken with salt and pepper.
Mix the Mayo and Parmesan:
In a small bowl, combine the mayonnaise, grated Parmesan cheese, garlic powder, onion powder, and Italian seasoning. Mix well until smooth.
Coat the Chicken:
Spread the mayo-Parmesan mixture evenly over the top of each chicken breast.
Add Breadcrumbs (Optional):
If you prefer a crispy topping, sprinkle breadcrumbs over the mayo-Parmesan coating.
Bake the Chicken:
Place the coated chicken breasts in the prepared baking dish.
Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and the topping is golden and bubbly. The internal temperature should reach 165°F (74°C).
Garnish and Serve:
Remove the chicken from the oven and let it rest for a few minutes.
Garnish with chopped fresh parsley before serving.
Serving Suggestions:
Serve the Mayo Parmesan Chicken with a side of roasted vegetables, mashed potatoes, or a fresh green salad.